Guidelines for Usage Of Teracyclic Compounds

Dosage is individualized. Take exactly as prescribed.

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Do not stop taking or change the dose unless directed by your doctor.

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Maprotiline - May be given as a single daily dose or in divided doses.

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Mirtazapine - Take in a single dose, preferably at bedtime. May be taken without regard to food.

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Remeron SolTabs- Open tablet blister pack with dry hands and place the tablet on the tongue. The tablet will disintegrate rapidly and can be swallowed with saliva. No water is needed. Do not chew the tablet, split the tablet, or store the tablet for later use.

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If a dose is missed, take it as soon as possible. If several hours have passed or it is nearing time for the next dose, do not double the dose to catch up, unless advised to do so by your doctor. If more than one dose is missed or it is necessary to establish a new dosage schedule, contact your doctor or pharmacist.

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Avoid the use of alcohol, barbiturates, or other CNS depressants (eg, tranquilizers) while taking this medicine.

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Contact your doctor if you experience sore throat, fever, chills, mouth sores, or other signs of infection. Pay particular attention to any f1u­like symptoms or other symptoms that might suggest infection.

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May cause drowsiness or dizziness. Alcohol use may increase this effect. Use caution while driving or performing other tasks requiring alertness, coordination, or physical dexterity.

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Allow at least 14 days between discontinuation of an MAO inhibitor anti­depressant (eg, phenelzine) and the start of therapy with this medicine. Also, allow at least 14 days after stopping this medicine before starting an MAO inhibitor.

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Maprotiline has been associated with seizures. This risk is higher in patients with a history of seizures, in patients taking phenothiazines (eg, promethazine) or withdrawing from benzodiazepines (eg, alprazolam).

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Inform your doctor if you are pregnant, become pregnant, are plan to become pregnant, or are breastfeeding.

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Maprotiline - Beneficial effects are sometimes seen within 3 to 7 days, although 2 to 3 weeks are usually necessary.

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Mirtazapine - Beneficial effects may take 1 to 4 weeks to occur.

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Lab tests may be required to monitor therapy. Be sure to keep appointments.

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Store room temperature (59 to 86°F) in a tightly closed container, away from light and moisture.